ID   URED_CUPMC              Reviewed;         293 AA.
AC   Q1LPT3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Rmet_0957;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000352; ABF07843.1; -; Genomic_DNA.
DR   RefSeq; WP_011515765.1; NC_007973.1.
DR   AlphaFoldDB; Q1LPT3; -.
DR   SMR; Q1LPT3; -.
DR   STRING; 266264.Rmet_0957; -.
DR   EnsemblBacteria; ABF07843; ABF07843; Rmet_0957.
DR   KEGG; rme:Rmet_0957; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000002429; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..293
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340499"
SQ   SEQUENCE   293 AA;  31470 MW;  F1EA71F8C6677C55 CRC64;
     MRHPDFPSQL AMTSAWHASL RLRFAARAGR TAMVERRHEG PLRVQKPLYP EGEICHGVVL
     HPPAGVAGGD RLDIDIAVAS GAHAVLATPG ATKWYKSLGR DAAQHVRIEV AAGGKLDWLP
     QENIVFDDAR ARITTDVVVA PGGSAIGWDA VVLGRQASGE RWASGALWLD TRVGDPDRAL
     WIEQSHFDGA SPLRGAVAGM DGLHILGTLW AIGPGATQEL AEALAEHLPY RADLRAGVTC
     LAGYGTATAQ SMLLLRVLGS DMEAVRHLMI DAWTVLRQPM HGVPARPLRL WST