ID   URED_CUPNH              Reviewed;         289 AA.
AC   O30332; O30333; Q0KCQ0;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=H16_A1080;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Piettre C., Toussaint A.;
RT   "Ralstonia eutropha H16 urease genes and proteins.";
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA74061.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y13732; CAA74060.1; -; Genomic_DNA.
DR   EMBL; Y13732; CAA74061.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AM260479; CAJ92221.1; -; Genomic_DNA.
DR   RefSeq; WP_011614865.1; NZ_CP039287.1.
DR   AlphaFoldDB; O30332; -.
DR   SMR; O30332; -.
DR   STRING; 381666.H16_A1080; -.
DR   EnsemblBacteria; CAJ92221; CAJ92221; H16_A1080.
DR   GeneID; 57643180; -.
DR   KEGG; reh:H16_A1080; -.
DR   PATRIC; fig|381666.6.peg.1464; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067603"
SQ   SEQUENCE   289 AA;  31138 MW;  FF866E95CF74E779 CRC64;
     MRHPDLPSSL TVPAAWQATL RLRFAQRGER TALTERRHQG PLLVQKPLYP EGGICHAVIL
     HPPAGVAGGD SLDIDVTVED GAHAVLATPG ATKWYKSLGR EAAQHVRLTV GAGARLDWLP
     QENIVFDDAR ARISTVLDVA PGGSAIGWDA VVLGRQASGE QWTRGALWLD TRVGTGERAL
     WIEQSHLEAE SPLRTAVAGL DGLNVLGTLW AVGEGATQEL AEALAEQLPY TPELRAGVTC
     LATSGQSMLL LRVLGRQMEA VRHVMVDSWQ ALRMPIHGVA ARPLRLWAT