ID   URED_CUPPJ              Reviewed;         289 AA.
AC   Q473R3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Reut_A0991;
OS   Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
OS   (strain JMP 134)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JMP134 / LMG 1197;
RX   PubMed=20339589; DOI=10.1371/journal.pone.0009729;
RA   Lykidis A., Perez-Pantoja D., Ledger T., Mavromatis K., Anderson I.J.,
RA   Ivanova N.N., Hooper S.D., Lapidus A., Lucas S., Gonzalez B.,
RA   Kyrpides N.C.;
RT   "The complete multipartite genome sequence of Cupriavidus necator JMP134, a
RT   versatile pollutant degrader.";
RL   PLoS ONE 5:E9729-E9729(2010).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000090; AAZ60370.1; -; Genomic_DNA.
DR   RefSeq; WP_011297174.1; NC_007347.1.
DR   AlphaFoldDB; Q473R3; -.
DR   SMR; Q473R3; -.
DR   STRING; 264198.Reut_A0991; -.
DR   EnsemblBacteria; AAZ60370; AAZ60370; Reut_A0991.
DR   KEGG; reu:Reut_A0991; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..289
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340498"
SQ   SEQUENCE   289 AA;  31028 MW;  033109EE4B83E11D CRC64;
     MRHPDFPSAV AVPPAWQASL RLRFAARGER TVLAARQHRG PLMVQKPLYP EGDICHAVIL
     HPPAGVAGGD TLDIALHAEA GTHAVIATPG ATKWYKSLGR DASQHVRLTV EEGARLDWLP
     QENIVFDDAR ARIATELSIA PGGSAIGWDA VVLGRQASGE QWNRGVLWLD TQVRCNGHAL
     WIEQSQLDAG SPLRGAVAGL DGMSVLGTLW AVGHGATQEL AESLAERLPY AAGLRAGVTC
     LSSPAQSMLL VRVLGRQMEA VRHVMVDAWS ALREPIHGVP ARPLRLWAT