URED_CYTH3
ID URED_CYTH3 Reviewed; 285 AA.
AC Q11VN0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=CHU_1264;
OS Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC
OS 15051 / NCIMB 9469 / D465).
OC Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Cytophagaceae;
OC Cytophaga.
OX NCBI_TaxID=269798;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465;
RX PubMed=17400776; DOI=10.1128/aem.00225-07;
RA Xie G., Bruce D.C., Challacombe J.F., Chertkov O., Detter J.C., Gilna P.,
RA Han C.S., Lucas S., Misra M., Myers G.L., Richardson P., Tapia R.,
RA Thayer N., Thompson L.S., Brettin T.S., Henrissat B., Wilson D.B.,
RA McBride M.J.;
RT "Genome sequence of the cellulolytic gliding bacterium Cytophaga
RT hutchinsonii.";
RL Appl. Environ. Microbiol. 73:3536-3546(2007).
CC -!- FUNCTION: Required for maturation of urease via the functional
CC incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC Rule:MF_01384}.
CC -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000255|HAMAP-Rule:MF_01384}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC Rule:MF_01384}.
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DR EMBL; CP000383; ABG58536.1; -; Genomic_DNA.
DR RefSeq; WP_011584651.1; NZ_FPJX01000009.1.
DR AlphaFoldDB; Q11VN0; -.
DR SMR; Q11VN0; -.
DR STRING; 269798.CHU_1264; -.
DR EnsemblBacteria; ABG58536; ABG58536; CHU_1264.
DR KEGG; chu:CHU_1264; -.
DR eggNOG; COG0829; Bacteria.
DR HOGENOM; CLU_021703_1_0_10; -.
DR OrthoDB; 1368450at2; -.
DR Proteomes; UP000001822; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR HAMAP; MF_01384; UreD; 1.
DR InterPro; IPR002669; UreD.
DR PANTHER; PTHR33643; PTHR33643; 1.
DR Pfam; PF01774; UreD; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT CHAIN 1..285
FT /note="Urease accessory protein UreD"
FT /id="PRO_0000346560"
SQ SEQUENCE 285 AA; 32101 MW; EE7E2EC995436BC3 CRC64;
MVKDTTHSIL EISTIHGKSS VTGSKIFRPL KIFALEKNKA CHLVFSNYGG GFVEGDSIDL
TIDCKADTVS AFSSQANTRI YRSEHGKTCK QTITGTVGEN ALVVFMGDPV VPHQKSIFEQ
HLFWKLEKNA VLLVIDWFEA GRILNGERFA FDSFFTELKI ESNGVPIVWD RFKMDPSQNN
MNSPGAFLDH SSYINIFLAG DENLTRVKSI ETQLRFLAAQ YFHEHIENKS ESLIRIGSAV
KVNEQVFMIR CSAKNNDLLQ PFVKALAEHM SDKELLGFNP FEGRN