ID   URED_DEIRA              Reviewed;         278 AA.
AC   Q9RYK1;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=DR_A0311;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AE001825; AAF12467.1; -; Genomic_DNA.
DR   PIR; D75585; D75585.
DR   RefSeq; NP_285634.1; NC_001264.1.
DR   RefSeq; WP_010889570.1; NZ_CP015082.1.
DR   AlphaFoldDB; Q9RYK1; -.
DR   SMR; Q9RYK1; -.
DR   STRING; 243230.DR_A0311; -.
DR   DNASU; 1798026; -.
DR   EnsemblBacteria; AAF12467; AAF12467; DR_A0311.
DR   KEGG; dra:DR_A0311; -.
DR   PATRIC; fig|243230.17.peg.3201; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_1_0; -.
DR   InParanoid; Q9RYK1; -.
DR   OMA; LMVFIVN; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002524; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340450"
SQ   SEQUENCE   278 AA;  29812 MW;  CF6FABE315256AA7 CRC64;
     MTTLGTPVSL GRRTRTGRLE LEFGVRHGQT ALLRDLQKAP LMVVRPFRLP CGTLMVFIVN
     PTGGVLGGDH SEIHVEAGAG TRVLILTQSA TRVQPSPGGE WATQELHFHV GVGARLEYYP
     ERTLPFAGSR FRQHLRADLG AGAEFGLLET LASGRVQMGE RLAWADYRSE VSVYAAQERV
     YLDRQHFRPG PHSRAPGVLG GNDYFASGVW VAGDSAAGRP AAESPTTAPG WASGLSAGGA
     VWARGVAATG PALDHAARQL REQVRHDLFG AAPLVLRR