ID   URED_ENT38              Reviewed;         274 AA.
AC   A4WEJ2;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Ent638_3463;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000653; ABP62122.1; -; Genomic_DNA.
DR   RefSeq; WP_015960450.1; NC_009436.1.
DR   AlphaFoldDB; A4WEJ2; -.
DR   SMR; A4WEJ2; -.
DR   STRING; 399742.Ent638_3463; -.
DR   EnsemblBacteria; ABP62122; ABP62122; Ent638_3463.
DR   KEGG; ent:Ent638_3463; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_6; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..274
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340452"
SQ   SEQUENCE   274 AA;  30835 MW;  8AF44014CD940C43 CRC64;
     MQGTPAKKHT HGWQASLALQ FCHTPEKTVL HSARHVGPLT VQRPFYPEEE TCHLYLLHPP
     GGIVGGDELN ISVQLDPNSH ALITMPGAGK FYRSSGPLAR LNQHFFLEEN ATLEWLPQDT
     IFFPGANAVL QSVFHLHHSS RLLAWELFCL GRPVINETFS HGTIESRLEV WLDDEPLLIE
     RQHLADGDLT TVANHPWIGT LLCYPASDAL LEGVREKLVT LDNFAGATLT DGLLSIRFLS
     HDNLICQRAM REIWQCLRPH VIAKTPHPPR IWQT