ID   URED_FLAJ1              Reviewed;         277 AA.
AC   A5FAE2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Fjoh_4831;
OS   Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC
OS   14942 / NCIMB 11054 / UW101) (Cytophaga johnsonae).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=376686;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101;
RX   PubMed=19717629; DOI=10.1128/aem.01495-09;
RA   McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G.,
RA   Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R.,
RA   Cheng Y.Q., Stein J.L.;
RT   "Novel features of the polysaccharide-digesting gliding bacterium
RT   Flavobacterium johnsoniae as revealed by genome sequence analysis.";
RL   Appl. Environ. Microbiol. 75:6864-6875(2009).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000685; ABQ07830.1; -; Genomic_DNA.
DR   RefSeq; WP_012026796.1; NZ_MUGZ01000004.1.
DR   AlphaFoldDB; A5FAE2; -.
DR   SMR; A5FAE2; -.
DR   STRING; 376686.Fjoh_4831; -.
DR   EnsemblBacteria; ABQ07830; ABQ07830; Fjoh_4831.
DR   KEGG; fjo:Fjoh_4831; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_6_0_10; -.
DR   OMA; IPFENAH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000006694; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..277
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346562"
SQ   SEQUENCE   277 AA;  31458 MW;  4170305B0BFEA027 CRC64;
     MINKLNIVSG FKEGRSYLKD AFFTRPFRIA DIKEDKTDPS LYLMLMSSSP GILDNDHYDI
     NIQIESESRL MLESQSYQRL FNMQNGAVQQ MNVSLADKST FSYVQHPIVP HEQSIFKAYN
     VFNLTDNCSL TVGEIITCGR KHSGEVFLFS KFQNLTEVFH NGKLVVKDNV LLQPLLADVQ
     TLGQMEGFTH QATLMYINTG IEDVESCIEL AYAELQSEEN IAFGVSKPFA NGMIVRVLGN
     GGEQLYNAFR KIQRKLWIAE EKLNIKSQVT DLAENYI