ID   URED_FRAAA              Reviewed;         298 AA.
AC   Q0RQS5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=FRAAL1440;
OS   Frankia alni (strain ACN14a).
OC   Bacteria; Actinobacteria; Frankiales; Frankiaceae; Frankia.
OX   NCBI_TaxID=326424;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ACN14a;
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAJ60098.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CT573213; CAJ60098.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041938919.1; NC_008278.1.
DR   AlphaFoldDB; Q0RQS5; -.
DR   SMR; Q0RQS5; -.
DR   STRING; 326424.FRAAL1440; -.
DR   KEGG; fal:FRAAL1440; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_055097_2_0_11; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000000657; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..298
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346563"
SQ   SEQUENCE   298 AA;  29876 MW;  A931A872D0548600 CRC64;
     MPTTTDAASP ARPRTGRTAV RAHASVRVER GPQGAPRLAE LRSDVPIVLR MTGVSPVRTG
     ARAGAGARAD PGPLPTMTVH LVNGAAGPLA GDDLRLDISV GGGVRLVLRS VAATVALPGR
     GPGPSRLTVT AEVADGGELD LGPEPTVVAD GADHQISTDV RLAATARLRL REEILLGRFG
     EPGGSILSTL RVDVAGGAEG PGADLAGGPF GWVPLLRQEL LLGPQVPGLR GPAQLGGARA
     VGSLLVVAPA WAGAGPDAAV AEGVARLPLT GPGYLVSALA DDAVTLRRRL TALADPTG