ID   URED_HAEIG              Reviewed;         271 AA.
AC   A5UH41;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=CGSHiGG_05930;
OS   Haemophilus influenzae (strain PittGG).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=374931;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PittGG;
RX   PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA   Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA   Ehrlich G.D.;
RT   "Characterization and modeling of the Haemophilus influenzae core and
RT   supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT   nontypeable strains.";
RL   Genome Biol. 8:R103.1-R103.18(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABR00097.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000672; ABR00097.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041174815.1; NC_009567.1.
DR   AlphaFoldDB; A5UH41; -.
DR   SMR; A5UH41; -.
DR   EnsemblBacteria; ABR00097; ABR00097; CGSHiGG_05930.
DR   KEGG; hiq:CGSHiGG_05930; -.
DR   HOGENOM; CLU_056339_6_0_6; -.
DR   Proteomes; UP000001990; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..271
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346566"
SQ   SEQUENCE   271 AA;  30385 MW;  260C3DD509480B23 CRC64;
     MNSKLSLSTK LSSNGKTQLA EYFAMPPFKV ITLPSYDDAW ANGLNAMQMS SSPGVLAGDL
     LEIDISLAKL TALSLNTQAF TRVQAMNEGD SAMQTTHILL AENSRLFYLP HPLVLHKDSV
     FKQKTLIEMD EQSELIYGEI VAIGRVLNDE RFAFRQFSSH LKIYALQNDG KKRPLVSDCI
     QWLPSKMNLT ALSQMENYSH QGSLTYLNLA KNNAEIKQQV QALQQQSAEE KDLLIGISQL
     NEYGLMVRVL GCRAEQIQKL FEKIGRLLKS V