ID   URED_HAEIN              Reviewed;         261 AA.
AC   P44397;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; Synonyms=ureH;
GN   OrderedLocusNames=HI_0535;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; L42023; AAC22193.1; -; Genomic_DNA.
DR   PIR; D64075; D64075.
DR   RefSeq; NP_438693.1; NC_000907.1.
DR   RefSeq; WP_010869001.1; NC_000907.1.
DR   AlphaFoldDB; P44397; -.
DR   SMR; P44397; -.
DR   STRING; 71421.HI_0535; -.
DR   DNASU; 949674; -.
DR   EnsemblBacteria; AAC22193; AAC22193; HI_0535.
DR   KEGG; hin:HI_0535; -.
DR   PATRIC; fig|71421.8.peg.554; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_6_0_6; -.
DR   OMA; IPFENAH; -.
DR   PhylomeDB; P44397; -.
DR   BioCyc; HINF71421:G1GJ1-548-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..261
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067623"
SQ   SEQUENCE   261 AA;  29088 MW;  6A64EFF0C407789F CRC64;
     MNSKLSLSTK LSSSGKTQLA EYFATPPFKV ITLPSYDDAW ANGLNAMQMS SSPGVLAGDL
     LEIDISLAKL TALSLNTQAF TRVQAMNEGD SAMQTTHILL AENSRLFYLP HPLVLHRDSV
     FKQQTQIEMG EQSELIYGEI VAIGRVLNDE RFAFRQFSSH LKIYALQNDG KKRPLVSDCI
     QWLPSKMNLT ALSQMENYSH QGSLTYLNLA KNNAEIKQQV QALQQQSTEE KDLLIGISQL
     NEYGLMVRVL GCRAEANSEI I