ID   URED_HALMA              Reviewed;         299 AA.
AC   Q75ZQ2; Q5V6L4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=pNG7127;
OS   Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM
OS   B-1809) (Halobacterium marismortui).
OG   Plasmid pNG700.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=272569;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809;
RX   PubMed=14981304; DOI=10.1271/bbb.68.397;
RA   Mizuki T., Kamekura M., DasSarma S., Fukushima T., Usami R., Yoshida Y.,
RA   Horikoshi K.;
RT   "Ureases of extreme halophiles of the genus Haloarcula with a unique
RT   structure of gene cluster.";
RL   Biosci. Biotechnol. Biochem. 68:397-406(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809; PLASMID=pNG700;
RX   PubMed=15520287; DOI=10.1101/gr.2700304;
RA   Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W.,
RA   Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E.,
RA   Hood L., Ng W.V.;
RT   "Genome sequence of Haloarcula marismortui: a halophilic archaeon from the
RT   Dead Sea.";
RL   Genome Res. 14:2221-2234(2004).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AY596296; AAV44838.1; -; Genomic_DNA.
DR   EMBL; AB119092; BAC84961.1; -; Genomic_DNA.
DR   RefSeq; WP_011222587.1; NZ_CP039137.1.
DR   AlphaFoldDB; Q75ZQ2; -.
DR   SMR; Q75ZQ2; -.
DR   EnsemblBacteria; AAV44838; AAV44838; pNG7127.
DR   GeneID; 40151399; -.
DR   KEGG; hma:pNG7127; -.
DR   PATRIC; fig|272569.17.peg.570; -.
DR   HOGENOM; CLU_056339_1_0_2; -.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000001169; Plasmid pNG700.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Plasmid; Reference proteome.
FT   CHAIN           1..299
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340536"
SQ   SEQUENCE   299 AA;  31190 MW;  C5EDF5CAD0F51642 CRC64;
     MAADAPHPAF EGYATEAVPQ AAVGSPGKDG VLELTFERTA DGTTLVHDYA TVPFHISGTL
     GYDPLPEADT VFIQSPTGGV AQGDRHDVSI TVGDEAVAHV STQSSTKVQT MTCNYAAADT
     TLSVGAGGHL DYVPEPTILH ADSRYLQELS VDLAPGATAV VSDVVVPGRL ARGERFEFER
     YLSRVRATGP DGHLFEDATH LTPGDEDPTA PGVLGEFTVY GTTFVLAPDH DEAELSDALH
     AVVTDGDARA GATALPNGAG VAVRALGDRA ETVQATLHAA WDHARIELLD APAPSGRKY