ID   URED_HALWD              Reviewed;         304 AA.
AC   Q18EB6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=HQ_3629A;
OS   Haloquadratum walsbyi (strain DSM 16790 / HBSQ001).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloquadratum.
OX   NCBI_TaxID=362976;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16790 / HBSQ001;
RX   PubMed=16820047; DOI=10.1186/1471-2164-7-169;
RA   Bolhuis H., Palm P., Wende A., Falb M., Rampp M., Rodriguez-Valera F.,
RA   Pfeiffer F., Oesterhelt D.;
RT   "The genome of the square archaeon Haloquadratum walsbyi: life at the
RT   limits of water activity.";
RL   BMC Genomics 7:169-169(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AM180088; CAJ53717.1; -; Genomic_DNA.
DR   RefSeq; WP_011572799.1; NC_008212.1.
DR   AlphaFoldDB; Q18EB6; -.
DR   SMR; Q18EB6; -.
DR   STRING; 362976.HQ_3629A; -.
DR   EnsemblBacteria; CAJ53717; CAJ53717; HQ_3629A.
DR   GeneID; 4194901; -.
DR   KEGG; hwa:HQ_3629A; -.
DR   eggNOG; arCOG04529; Archaea.
DR   HOGENOM; CLU_056339_1_0_2; -.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000001975; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..304
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346614"
SQ   SEQUENCE   304 AA;  33047 MW;  73AE92B61266731A CRC64;
     MSTDSDHTHP IPPAFQEYDT QKLRQSPAFG HGKHGIADLV VGREDNKPTR LLSDFLRVPY
     HLSGTLDSDP VDELITVCLQ DPTGAITQGD RHSLTVTARP DAYAHITNQS ASKVQTMKAS
     YAHLEATLIA ESGAYLEYLP EPTILNEDAR CLQTTTVEMA PDATVIVGDV FVPDGLSAHE
     PFSFDHYHSR TDARVEQRLI CADAVNLQPA QRDPRNLATI GEYTVIGNLY VFSPGADVEA
     IAEMVHQRLT DHEGAAGVST LRNEAGITVR ALGDRSTDVT AAIEAAWDET RRELLGVGAP
     LGDR