ID   URED_KLEP7              Reviewed;         274 AA.
AC   A6TE39;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=KPN78578_33990; ORFNames=KPN_03464;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000647; ABR78860.1; -; Genomic_DNA.
DR   RefSeq; WP_002916869.1; NC_009648.1.
DR   AlphaFoldDB; A6TE39; -.
DR   SMR; A6TE39; -.
DR   STRING; 272620.KPN_03464; -.
DR   EnsemblBacteria; ABR78860; ABR78860; KPN_03464.
DR   KEGG; kpn:KPN_03464; -.
DR   HOGENOM; CLU_056339_0_0_6; -.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..274
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340458"
SQ   SEQUENCE   274 AA;  30212 MW;  4A564CD65CBDC1F9 CRC64;
     MHGTVLPPLK KGWQATLDLR FHQAGGKTVL ASAQHVGPLT VQRPFYPEEE TCHLYLLHPP
     GGIVGGDELT ISAHLAPGCH TLITMPGASK FYRSSGAQAL VRQQLTLAPQ ATLEWLPQDA
     IFFPGANARL FTTFHLCASS RLLAWDLLCL GRPVIGETFS HGTLSNRLEV WVDDEPLLVE
     RLQLQEGELS SVAERPWVGT LLCYPATDAL LDGVRDALAP LGLYAGASLT DRLLTVRFLS
     DDNLICQRVM RDVWQFLRPH LTGKSPVLPR IWLT