ID   URED_KLEPN              Reviewed;         270 AA.
AC   Q02944;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IA551;
RX   PubMed=8497192; DOI=10.1111/j.1365-2958.1993.tb01215.x;
RA   Collins C.M., Gutman D.M., Laman H.;
RT   "Identification of a nitrogen-regulated promoter controlling expression of
RT   Klebsiella pneumoniae urease genes.";
RL   Mol. Microbiol. 8:187-198(1993).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; L07039; AAA25146.1; -; Genomic_DNA.
DR   PIR; S32937; S32937.
DR   AlphaFoldDB; Q02944; -.
DR   SMR; Q02944; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..270
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067612"
SQ   SEQUENCE   270 AA;  29954 MW;  EE9E01A1E8D4FAA8 CRC64;
     MLPPLKKGWQ RTLDLRFQQA GGKTVLASAQ HVGPLTVQRP FYPEEETCHL YLLHPPGGIV
     GGDELTISAH LAPGCHTLIT MPGASKFYRS SGAQALVRQQ LTLAPQATLE WLPQDAIFFP
     GANARLFTTF HLCAFSRLLA WDLLCLGRPV IGETFSHGTL SNRLEVWVDD EPLLVERLQL
     QEGELSSVAE RPWVGTLLCY PATDALLDGV RDALAPLGLY AGASLTDRLL TVRFLSDDNL
     ICQRVMRDVW QFLRPHLTGK SPVLPRIWLT