ID   URED_KOCRD              Reviewed;         364 AA.
AC   B2GI02;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=KRH_21670;
OS   Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201).
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Kocuria.
OX   NCBI_TaxID=378753;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9341 / DSM 348 / NBRC 103217 / DC2201;
RX   PubMed=18408034; DOI=10.1128/jb.01853-07;
RA   Takarada H., Sekine M., Kosugi H., Matsuo Y., Fujisawa T., Omata S.,
RA   Kishi E., Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Complete genome sequence of the soil actinomycete Kocuria rhizophila.";
RL   J. Bacteriol. 190:4139-4146(2008).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAG30514.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AP009152; BAG30514.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; B2GI02; -.
DR   SMR; B2GI02; -.
DR   STRING; 378753.KRH_21670; -.
DR   EnsemblBacteria; BAG30514; BAG30514; KRH_21670.
DR   KEGG; krh:KRH_21670; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_0_11; -.
DR   Proteomes; UP000008838; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..364
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346569"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  38634 MW;  7B69572E546387FC CRC64;
     MDQDRSGAAD AGNPDPGRGP AGSAEARNGA AAASSPAEWA GQLRLSVAER NGRSYAARQF
     HEGALRVLRP HYLDRSGQVT YTVVNPGGAY LGADAYLLDV AVERDASLVL TTQSATKVYR
     TPQGPATQDM TVRLGPGSCL EHVPDQLIVY RGGSYLQRTR VDMDPAASLL LAEVVTPGWS
     PSGESFAYDE LRLRTEVRVT PPEVPAPAAP DRGAPAAEAQ DRPADPCHVP GGPDRAASSG
     GTGAAPAGER ARRLVVDQLR IRPDAHGGMS GVGFMEGFSH TGQLLVADAR LDDELYERLC
     ELVDASGTHS GITRAGTGEP YGVRCVCVRS LAHSTSAITA LHRAVVDELR QRWRGQSPLR
     LRKY