ID   URED_LEPCP              Reviewed;         278 AA.
AC   B1Y3W7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Lcho_1092;
OS   Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS   discophora (strain SP-6)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Leptothrix.
OX   NCBI_TaxID=395495;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51168 / LMG 8142 / SP-6;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT   "Complete sequence of Leptothrix cholodnii SP-6.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP001013; ACB33361.1; -; Genomic_DNA.
DR   RefSeq; WP_012346123.1; NC_010524.1.
DR   AlphaFoldDB; B1Y3W7; -.
DR   SMR; B1Y3W7; -.
DR   STRING; 395495.Lcho_1092; -.
DR   EnsemblBacteria; ACB33361; ACB33361; Lcho_1092.
DR   KEGG; lch:Lcho_1092; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CHHVLVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001693; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346570"
SQ   SEQUENCE   278 AA;  30344 MW;  AC9CE55BBE1631E7 CRC64;
     MSWHGHLQLH YRHDPNEDRT VAHDRHHGPL RVLQRLYPEG PSICHHVLVH PPGGIVGGDT
     LEVDLDLAPG SHALITTPGA TRYYRSAGEV ARQQVRARLA EGSRLEWLPL ETIAYDACIA
     ENSLRFEIAP GAMMMGWDLL ALGLPAAGKP WQRGSYLQQL ELPGIWLERA RIDAADARLL
     DSPLGWAGQR VLGTFWLAGG DALPKGLSDA LIESARALIG DSALAATAGV SAPHANTVVL
     RVLAPRVEPA MHLLGAIRAA WRSIAWHLDP CVPRIWRT