ID   URED_METFK              Reviewed;         285 AA.
AC   Q1H0E9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Mfla_1770;
OS   Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=265072;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KT / ATCC 51484 / DSM 6875;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Brettin T., Bruce D., Han C., Tapia R., Saunders E., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Kyrpides N., Anderson I., Richardson P.;
RT   "Complete sequence of Methylobacillus flagellatus KT.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000284; ABE50038.1; -; Genomic_DNA.
DR   RefSeq; WP_011479992.1; NC_007947.1.
DR   AlphaFoldDB; Q1H0E9; -.
DR   SMR; Q1H0E9; -.
DR   STRING; 265072.Mfla_1770; -.
DR   EnsemblBacteria; ABE50038; ABE50038; Mfla_1770.
DR   KEGG; mfa:Mfla_1770; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002440; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..285
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340464"
SQ   SEQUENCE   285 AA;  31464 MW;  54DC9994DE62B104 CRC64;
     MDDVNTKTAA WADKRWQALL ALDFSSRAGR TTLIGKRHQG PLVVQKMLYP EGDEVCHGII
     IHPPGGVAGG DQLQLQATLE ASARALLTTP GAGKWYKANQ LSASQAVRFH LAANSCLEWL
     PQENILFDGS NVHFSSEIDL AEGAVFCGWD ILCFGRQARG ERWSEGELRQ VMQVRREGRL
     IWNERLFAQP DSLVMRSGIG LKGMPVNGSL VVAAGTVPVE IIEACRAIEA RGDAHYGVTA
     LPEILSARYI GASSEAAKEY FERLWQVLRP WYAARPATRP RIWNT