ID   URED_MICAN              Reviewed;         270 AA.
AC   B0JNA9;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=MAE_04510;
OS   Microcystis aeruginosa (strain NIES-843 / IAM M-2473).
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Chroococcales;
OC   Microcystaceae; Microcystis.
OX   NCBI_TaxID=449447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-843 / IAM M-247;
RX   PubMed=18192279; DOI=10.1093/dnares/dsm026;
RA   Kaneko T., Nakajima N., Okamoto S., Suzuki I., Tanabe Y., Tamaoki M.,
RA   Nakamura Y., Kasai F., Watanabe A., Kawashima K., Kishida Y., Ono A.,
RA   Shimizu Y., Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M.,
RA   Nakazaki N., Nakayama S., Yamada M., Tabata S., Watanabe M.M.;
RT   "Complete genomic structure of the bloom-forming toxic cyanobacterium
RT   Microcystis aeruginosa NIES-843.";
RL   DNA Res. 14:247-256(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AP009552; BAG00273.1; -; Genomic_DNA.
DR   RefSeq; WP_012264105.1; NC_010296.1.
DR   AlphaFoldDB; B0JNA9; -.
DR   SMR; B0JNA9; -.
DR   STRING; 449447.MAE_04510; -.
DR   PaxDb; B0JNA9; -.
DR   EnsemblBacteria; BAG00273; BAG00273; MAE_04510.
DR   KEGG; mar:MAE_04510; -.
DR   PATRIC; fig|449447.4.peg.425; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_3; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   BioCyc; MAER449447:MAE_RS02075-MON; -.
DR   Proteomes; UP000001510; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..270
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346581"
SQ   SEQUENCE   270 AA;  30533 MW;  BC80E43E3A2E89C9 CRC64;
     MWQGNLELIY KQKNLATEIN HVYATAPLKV QRPFYPEGKN LCHTVILHTA GGIVGGDVLQ
     QKIHLQAATN ALITTASAGK VYQSNGQMAQ QLIEIKIDDN ASLEWLPQET IIFNGAAFRQ
     HLRVDLGENS SWLGWEITRF GRSARGEKFL AGEWHSNWEI WRSGQPLWLD RSCLLGGKMI
     EGFSGLNDSA LIGTLVYIGQ PVGRNLIEKV RDFSLEGERG VTNTLGDGLL CRYRGNSSGE
     VRQWFQQVWQ ILRREMSDQE AIIPRVWLSW