ID   URED_MYCGI              Reviewed;         273 AA.
AC   A4T7D6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Mflv_1683;
OS   Mycolicibacterium gilvum (strain PYR-GCK) (Mycobacterium gilvum (strain
OS   PYR-GCK)).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350054;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PYR-GCK;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Miller C., Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000656; ABP44165.1; -; Genomic_DNA.
DR   RefSeq; WP_011892579.1; NC_009338.1.
DR   AlphaFoldDB; A4T7D6; -.
DR   SMR; A4T7D6; -.
DR   STRING; 350054.Mflv_1683; -.
DR   EnsemblBacteria; ABP44165; ABP44165; Mflv_1683.
DR   KEGG; mgi:Mflv_1683; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_1_0_11; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..273
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340465"
SQ   SEQUENCE   273 AA;  29133 MW;  B0024A783D559F20 CRC64;
     MTAPTIQPGE LGIEVVADSA GRTRTASLRQ RYPQRVTMPL HCDPDRPGAV TLCVQSPSGG
     TFSDDELRTT VACRAGSHLH LTTQSATQVF AGDGAGARHH LDFTVDRGAA LEYYPGTVIP
     HTDSTFTQTI EVNVETGGLY LGWEAVAAGR LAHGERYGYH TYDSAILARV DGRAVARDRQ
     VIRPGTDAMS LLEGDYLATL LVVAPGADIE ALLRRLRATL DDGSGVSGGA GRLPAHAGVF
     LRLIAQRAPD LHRARTDLFA AARRELLPGK DES