ID   URED_NATPD              Reviewed;         299 AA.
AC   Q3IRZ2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=NP_2016A;
OS   Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS   8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC   2260 / Gabara;
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CR936257; CAI49099.1; -; Genomic_DNA.
DR   RefSeq; WP_011322728.1; NC_007426.1.
DR   AlphaFoldDB; Q3IRZ2; -.
DR   SMR; Q3IRZ2; -.
DR   STRING; 348780.NP_2016A; -.
DR   EnsemblBacteria; CAI49099; CAI49099; NP_2016A.
DR   GeneID; 3703451; -.
DR   KEGG; nph:NP_2016A; -.
DR   eggNOG; arCOG04529; Archaea.
DR   HOGENOM; CLU_056339_1_0_2; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 61197at2157; -.
DR   Proteomes; UP000002698; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..299
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346615"
SQ   SEQUENCE   299 AA;  31799 MW;  850292A06622D81D CRC64;
     MSAVPDAFQR YGAESLAQAP AFGPGKDGVF EATLARTGDR DTRLLRDYTK VPYHLTGTLD
     TDPAPGLTTL CLQEPTGGVA QGDRHSITVT AREGARARVT TQSATKVHSM QANYAHLDAT
     LEAGPDAHLE YVPGPTIVNE DARCLQTVAV DLAPSATVVV ADVFVPGGLS AHEPFDFDHY
     HSRLEARCEE RLVCADAVDL HPADGDPRDP ATVADYDVVG TLYVLAPEAD TEVLAEAIHA
     RFDAHDAVTA GVSALPYESG VSVRVLGTRS ADVTDAVRDA WDASRQELLG VGIPADRRY