ID   URED_NITMU              Reviewed;         279 AA.
AC   Q2Y9N0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Nmul_A1238;
OS   Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Nitrosomonadaceae; Nitrosospira.
OX   NCBI_TaxID=323848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25196 / NCIMB 11849 / C 71;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC
RT   25196.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABB74541.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000103; ABB74541.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041352427.1; NZ_FNVK01000013.1.
DR   AlphaFoldDB; Q2Y9N0; -.
DR   SMR; Q2Y9N0; -.
DR   STRING; 323848.Nmul_A1238; -.
DR   EnsemblBacteria; ABB74541; ABB74541; Nmul_A1238.
DR   KEGG; nmu:Nmul_A1238; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002718; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..279
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340467"
SQ   SEQUENCE   279 AA;  30722 MW;  E69D7DD73BB7F01C CRC64;
     MASDSPLRAH LRLKFAESSG ITRMVERDHH GPLLVQKPLY PEGYEVCQAV VIHPPGGVVA
     GDELGIRVHV GPSAHAQITS PGATKWYKSK GRTARQHVYL HAEAGGVLEW MPQETIFFNN
     ARVMLHHEVE LEKDSVYMSC EILCFGRTAF GESFDSGEIK QHTSIRQEGK LVWFEKLRLE
     GGSKAMNGRL ALAGRAVCAT FIMSGKPLPA QAIDLVREEA VRIGGESGQV GITQLKSLLV
     ARFLGDSSEV ARHVMLCIWR AVRPITLGRP AIVPRSWNT