ID   URED_PARXL              Reviewed;         293 AA.
AC   Q144D8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Bxeno_A0763;
GN   ORFNames=Bxe_A3688;
OS   Paraburkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LB400;
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M., Lao V.,
RA   Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A., Marx C.J.,
RA   Parnell J.J., Ramette A., Richardson P., Seeger M., Smith D., Spilker T.,
RA   Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B., Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome
RT   shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000270; ABE29301.1; -; Genomic_DNA.
DR   RefSeq; WP_011487085.1; NZ_CP008760.1.
DR   AlphaFoldDB; Q144D8; -.
DR   SMR; Q144D8; -.
DR   STRING; 266265.Bxe_A3688; -.
DR   EnsemblBacteria; ABE29301; ABE29301; Bxe_A3688.
DR   KEGG; bxe:Bxe_A3688; -.
DR   PATRIC; fig|266265.5.peg.784; -.
DR   eggNOG; COG0829; Bacteria.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001817; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..293
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340444"
SQ   SEQUENCE   293 AA;  31070 MW;  27ABFE36C1C359EC CRC64;
     MSLHENHATL ATAQAGAHSQ WRARLELGFV REGERTTLKH RLHDGPLRVQ RPLYPEGYGV
     CHAVIVHPPG GIAGGDQLAI DVDVGAGAHA VIATPGATKW YKSNGRAAQQ CVGVRVGAGG
     KLDWLPQNNI VFDQANAKLD FSLMLGDGAT ALGWDATQLG RQAAGERWSE GSLHAVSRIV
     GADGELLWFE RASLAANDSL REAAQGLDGF SAYGTLWAVG AACDDALAEA LTAQLGFDES
     IRAAASCVTS GVLVVRAVSR SMEMLQKALT RCWVQLRPVV HGVQGVPLRI WAT