ID   URED_POLSJ              Reviewed;         276 AA.
AC   Q12DM9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Bpro_1414;
OS   Polaromonas sp. (strain JS666 / ATCC BAA-500).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Polaromonas; unclassified Polaromonas.
OX   NCBI_TaxID=296591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JS666 / ATCC BAA-500;
RX   PubMed=18723656; DOI=10.1128/aem.00197-08;
RA   Mattes T.E., Alexander A.K., Richardson P.M., Munk A.C., Han C.S.,
RA   Stothard P., Coleman N.V.;
RT   "The genome of Polaromonas sp. strain JS666: insights into the evolution of
RT   a hydrocarbon- and xenobiotic-degrading bacterium, and features of
RT   relevance to biotechnology.";
RL   Appl. Environ. Microbiol. 74:6405-6416(2008).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000316; ABE43363.1; -; Genomic_DNA.
DR   RefSeq; WP_011482362.1; NC_007948.1.
DR   AlphaFoldDB; Q12DM9; -.
DR   SMR; Q12DM9; -.
DR   STRING; 296591.Bpro_1414; -.
DR   EnsemblBacteria; ABE43363; ABE43363; Bpro_1414.
DR   KEGG; pol:Bpro_1414; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_0_0_4; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001983; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..276
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340472"
SQ   SEQUENCE   276 AA;  29832 MW;  D719EB6E85BE0D2D CRC64;
     MTWNATLALD YTRQAGKTVA HFRHSGPLRI LQSLYPEGDA ICHNVIVHPP GGLVGGDTLD
     LQFSASAGAH GLITTPGATR FYRSTGEPAL QRTHLTLEAG ARMEWLPLEA ICYSGCLAEN
     HLTMTLAPGA ELIGWDITAL GLPAASLPFA HGSFCQHIEV PGVWLERARI QASDTLLMSS
     PLGMAGHRCV ASLFFVAGSK LDRHRRQQAL DTARQIIEAH PLSATAGATS PDGQVVVVRV
     LAPVVEPAMA LLRQVWLAWR SHFWQQAASS PRIWSM