ID   URED_PROM1              Reviewed;         307 AA.
AC   A2C4R9;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=NATL1_19231;
OS   Prochlorococcus marinus (strain NATL1A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL1A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000553; ABM76479.1; -; Genomic_DNA.
DR   RefSeq; WP_011824455.1; NC_008819.1.
DR   AlphaFoldDB; A2C4R9; -.
DR   SMR; A2C4R9; -.
DR   STRING; 167555.NATL1_19231; -.
DR   EnsemblBacteria; ABM76479; ABM76479; NATL1_19231.
DR   KEGG; pme:NATL1_19231; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_4_0_3; -.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000002592; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..307
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346586"
SQ   SEQUENCE   307 AA;  34898 MW;  03574FE8C1533822 CRC64;
     MKSQWHGTCD LRLFKSSRSN NKDVVKTIHQ AKCTAPLKVM RVFNDKKDGR CEIPILHSAG
     GIVGGDQLTI NVNAEEDSIA ICSSVAAQKV YGSRGRSKLN PQGSWANQKC FFQIKKNSDF
     EWIPQELIVY QGGLFEQNMT VNLDLSSSFL CVDLVRLGRT AAEEQLGNGV WRSSLEIFRD
     NNQGKHYEFS DRLELSGEAL KSIHGLEQKP VFGSLTWITP KKIKQKDLSD LLVECREQRA
     GLEGFMTCSL LENGISARYT GSSTQSARFW FYRIWSLTRI LRKLSMPEYM RIWPMQENPS
     RDKKCPS