ID   URED_PROM3              Reviewed;         299 AA.
AC   A2CDZ8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=P9303_29781;
OS   Prochlorococcus marinus (strain MIT 9303).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MIT 9303;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000554; ABM79708.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2CDZ8; -.
DR   SMR; A2CDZ8; -.
DR   STRING; 59922.P9303_29781; -.
DR   EnsemblBacteria; ABM79708; ABM79708; P9303_29781.
DR   KEGG; pmf:P9303_29781; -.
DR   HOGENOM; CLU_056339_4_0_3; -.
DR   OMA; CQHIIVH; -.
DR   BioCyc; PMAR59922:G1G80-2614-MON; -.
DR   Proteomes; UP000002274; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..299
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340477"
SQ   SEQUENCE   299 AA;  33094 MW;  0FAA53EE88A7A7F2 CRC64;
     MTGDRPWHGQ CSLQLISKTA ADDLQSQLTV HQSQCTAPFK IQRANLDDDG RCQLPLLHTA
     GGLVGGDQLS VNVKAGASSR GLVTSVAAQK VYGSVGRSKQ HPKGLWASQE CHFELATNAD
     LEWLPQELVV FQGGLYKQRM QVELQPKASF LSAEVVRLGR TAAGETLNEG AWRSSLEICR
     QTPIGRQWEL VDQLELNSDV LQNLHGMGRQ PVFGSFVWAA PDPLTAEVME TLLRNCRTDR
     ANLEGSMACG GLDQGLVARY IGPSSQAARQ WFTRIWARTR QLRRLSTPQP PREWPLQEE