ID   URED_PROMP              Reviewed;         297 AA.
AC   Q7V1B3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=PMM0966;
OS   Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / NIES-2087 /
OS   MED4).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1986 / NIES-2087 / MED4;
RX   PubMed=12917642; DOI=10.1038/nature01947;
RA   Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA   Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA   Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA   Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA   Chisholm S.W.;
RT   "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT   differentiation.";
RL   Nature 424:1042-1047(2003).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; BX548174; CAE19425.1; -; Genomic_DNA.
DR   RefSeq; WP_011132599.1; NC_005072.1.
DR   AlphaFoldDB; Q7V1B3; -.
DR   SMR; Q7V1B3; -.
DR   STRING; 59919.PMM0966; -.
DR   EnsemblBacteria; CAE19425; CAE19425; PMM0966.
DR   KEGG; pmm:PMM0966; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_4_0_3; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001026; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..297
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340480"
SQ   SEQUENCE   297 AA;  33494 MW;  B303BB68387D6840 CRC64;
     MAKSSWEGNC FLNFFNNKSS SGKDDKTIFK SKFTSPYKLL KCSYDQEGRC ILPILHTAGG
     LVGGDLLEFE ANIGINSKVL LTTSSAQKVY GSVGRSKINP EGTFSSQKTK ISILDNSHLE
     YLPQETIVFA NGLYSQEFNI KISDNSSFLF TDLIRLGRSS AGESIESGVF RSKLEIMRNG
     NLCDDWEFVD QIELTKFSFE AKSGMDFKPV FGSLIWICEK EFPITKISYL KEKIKIIFKE
     NNNYLSLGTL ENGLSIRFLG TSSQDARKCF FSIWTQIRTV CGFCKPEYQG VWPLQDL