ID   URED_PROMT              Reviewed;         307 AA.
AC   Q46IY6;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=PMN2A_1052;
OS   Prochlorococcus marinus (strain NATL2A).
OC   Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=59920;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NATL2A;
RX   PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA   Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA   Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA   Richardson P., Chisholm S.W.;
RT   "Patterns and implications of gene gain and loss in the evolution of
RT   Prochlorococcus.";
RL   PLoS Genet. 3:2515-2528(2007).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000095; AAZ58542.1; -; Genomic_DNA.
DR   RefSeq; WP_011295397.1; NC_007335.2.
DR   AlphaFoldDB; Q46IY6; -.
DR   SMR; Q46IY6; -.
DR   STRING; 59920.PMN2A_1052; -.
DR   EnsemblBacteria; AAZ58542; AAZ58542; PMN2A_1052.
DR   KEGG; pmn:PMN2A_1052; -.
DR   HOGENOM; CLU_056339_4_0_3; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   PhylomeDB; Q46IY6; -.
DR   Proteomes; UP000002535; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..307
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346587"
SQ   SEQUENCE   307 AA;  34801 MW;  2EBAC3461CBD4C6F CRC64;
     MKSQWHGTCD LRLFKSSSSN NKDIVKTIHQ AKSTAPLKVM RVFNDKKDGR CEIPILHSAG
     GIVGGDQLTI NVNAEEDSIA ICSSVAAQKV YGSRGRSKLN PQGSWANQKC FFQIKQNSDF
     EWMPQELIVY QGGLFEQNMT VNLDPSSSFL CVDLVRLGRT AAEEQLGSGV WRSSLEIFRD
     NNQGKHYEFS DRLELSGEAL KSIHGLEQKP VFGSLTWITP KKIMQKDLSD LLVECRQQRA
     GLEGFMTCSL LENGISARYT GSSTQSARFW FYRIWSLTRV LRKLSMPEYM RIWPMQENPS
     RDIKCPL