ID   URED_PSEAB              Reviewed;         280 AA.
AC   Q02FF5;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=PA14_64335;
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA   Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000438; ABJ15649.1; -; Genomic_DNA.
DR   RefSeq; WP_003116109.1; NZ_CP034244.1.
DR   AlphaFoldDB; Q02FF5; -.
DR   SMR; Q02FF5; -.
DR   PRIDE; Q02FF5; -.
DR   EnsemblBacteria; ABJ15649; ABJ15649; PA14_64335.
DR   KEGG; pau:PA14_64335; -.
DR   HOGENOM; CLU_056339_0_0_6; -.
DR   OMA; CQHIIVH; -.
DR   BioCyc; PAER208963:G1G74-5435-MON; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..280
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340484"
SQ   SEQUENCE   280 AA;  30775 MW;  1811BDD37F7B41DF CRC64;
     MTAALPDLSF HPAWHAQLEL AYARAGDATR PVTRRHAGPL RVQKHLYAEG PEVCQHILVH
     PPGGIAGGDS LAFDVRLGER AWAQLTSPGA AKWYRAACPS RQTLEIHLEP GATLEWLPQE
     SIVFAGAQAE LETRIQLRGD ARLFYWDMVA LGRPASGERF ASGHFVAALD IRRDDRLLWH
     ERQRIDGGDR LLDSPIGLAG HPVLATLVAS GEIDTDLLQR CRALPCAGRG NLSQLPGGLL
     VARCLADEAL HARAWLIELW RLLRPALLGR EAVPPRIWST