ID   URED_PSEAE              Reviewed;         280 AA.
AC   Q9HUU9;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=PA4864;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AE004091; AAG08249.1; -; Genomic_DNA.
DR   PIR; D83037; D83037.
DR   RefSeq; NP_253551.1; NC_002516.2.
DR   RefSeq; WP_003112316.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; Q9HUU9; -.
DR   SMR; Q9HUU9; -.
DR   STRING; 287.DR97_2215; -.
DR   PaxDb; Q9HUU9; -.
DR   EnsemblBacteria; AAG08249; AAG08249; PA4864.
DR   GeneID; 879776; -.
DR   KEGG; pae:PA4864; -.
DR   PATRIC; fig|208964.12.peg.5097; -.
DR   PseudoCAP; PA4864; -.
DR   HOGENOM; CLU_056339_0_0_6; -.
DR   InParanoid; Q9HUU9; -.
DR   OMA; CQHIIVH; -.
DR   PhylomeDB; Q9HUU9; -.
DR   BioCyc; PAER208964:G1FZ6-4978-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..280
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000287731"
SQ   SEQUENCE   280 AA;  30759 MW;  8263BDC1729B4C32 CRC64;
     MTAALPDLSF HPAWHAQLEL AYARAGDATR PVTRRHAGPL RVQKHLYAEG PEVCQHILVH
     PPGGIAGGDS LAFDVRLGER AWAQLTSPGA AKWYRAACPA RQTLEIHLEP GATLEWLPQE
     SIVFAGAQAE LETRIQLRGD ARLFYWDMVA LGRPASGERF ASGHFVAALD IRRDDRLLWH
     ERQRIDGGDR LLDSPIGLAG HPVLATLVAS GEIDTDLLQR CRALPCAGRG NLSQLPGGLL
     VARCLADEAL HARAWLIELW RLLRPALLGR EAVPPRIWST