ID   URED_RHIEC              Reviewed;         273 AA.
AC   Q2K511;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=RHE_CH03311;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABC92075.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000133; ABC92075.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_042118949.1; NC_007761.1.
DR   AlphaFoldDB; Q2K511; -.
DR   SMR; Q2K511; -.
DR   STRING; 347834.RHE_CH03311; -.
DR   EnsemblBacteria; ABC92075; ABC92075; RHE_CH03311.
DR   KEGG; ret:RHE_CH03311; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_2_0_5; -.
DR   Proteomes; UP000001936; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..273
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340501"
SQ   SEQUENCE   273 AA;  29340 MW;  E277CE378BB9C98B CRC64;
     MTIVATATRP QRAEGRGHLA AKLLDGRTRI RELYQEGAAK IRLPNTFDAS MEAVIINTAG
     GLTGGDRMDW SVVAGAGTKI DVTTQACEKI YKASAGVAEV TTRIEAGAGA RVDWLPQETI
     LFDRAALFRR LDVDLDESAE FLAVEAVLLG RKAMGETVDT GLFRDRWRIR RSGRLIHAEE
     LRFSEGVAAL SARQAVLGGQ VAFATLLYAG PLAEAYLGRV RSLLEGAMGG ASAWGDKLVV
     RLAAADGFTL RKILIPVISV LRNGAPVPKV WNL