ID   URED_RHIL3              Reviewed;         273 AA.
AC   Q1MCV4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=RL3736;
OS   Rhizobium leguminosarum bv. viciae (strain 3841).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=216596;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3841;
RX   PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA   Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F.,
RA   Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H.,
RA   East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I.,
RA   Chillingworth T., Clarke K., Cronin A., Davis P., Fraser A., Hance Z.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J.;
RT   "The genome of Rhizobium leguminosarum has recognizable core and accessory
RT   components.";
RL   Genome Biol. 7:R34.1-R34.20(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AM236080; CAK09226.1; -; Genomic_DNA.
DR   RefSeq; WP_011653189.1; NC_008380.1.
DR   AlphaFoldDB; Q1MCV4; -.
DR   SMR; Q1MCV4; -.
DR   STRING; 216596.RL3736; -.
DR   EnsemblBacteria; CAK09226; CAK09226; RL3736.
DR   KEGG; rle:RL3736; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_2_0_5; -.
DR   OMA; MARFCAQ; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000006575; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..273
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340503"
SQ   SEQUENCE   273 AA;  29261 MW;  581FE000DD154237 CRC64;
     MTIAAAGTRP QRAEGRGHLA AKLFDGRTRI RELYQEGAAK IRLPDTFDAS MEAVIINTAG
     GLTGGDRMDW SVDAGPGTRI DVTTQACEKI YKASAGIAEV ATSIKVGAQA RVDWLPQETI
     LFDRAALFRR LDVDLDESAE FLAVEAVLLG RKAMGEAVVS GLFRDRWRIR RSGQLIHAEE
     LRLSEGVAAL AARQAVLGGQ VAFATLLYAG PLLEAYLSKV RPLVEGSMGG ASAWNGKLVV
     RLAAADGFSL RKILIPVISA LRNGAPVPKV WNL