ID   URED_SINMW              Reviewed;         277 AA.
AC   A6UC41;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Smed_2389;
OS   Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=366394;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WSM419;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA   Richardson P.;
RT   "Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000738; ABR61221.1; -; Genomic_DNA.
DR   RefSeq; WP_012066612.1; NC_009636.1.
DR   RefSeq; YP_001328056.1; NC_009636.1.
DR   AlphaFoldDB; A6UC41; -.
DR   SMR; A6UC41; -.
DR   STRING; 366394.Smed_2389; -.
DR   EnsemblBacteria; ABR61221; ABR61221; Smed_2389.
DR   GeneID; 61611371; -.
DR   KEGG; smd:Smed_2389; -.
DR   PATRIC; fig|366394.8.peg.5572; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_2_0_5; -.
DR   OMA; MARFCAQ; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001108; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..277
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340518"
SQ   SEQUENCE   277 AA;  29400 MW;  6A4B60CACEED40FE CRC64;
     MEAAAAIAPQ RAWGKGRLVA KTGGARTRIA GLYQEGCAKI RLPRTFDASM EAVLINSSGG
     VTGGDRLAWE FEAGEGTNLT LTTQACEKVY KASVDTAVVA TRISVAARGH VDWLPQESIL
     FDRSALSRSL EVDLAPDASF LALEAVLIGR KAMGETVRSG LFRDHWRIRS GGALVHAENL
     ALAGDIAALG SRRAVLDGAV AFATLVYVAP DCEALLPRLR TSLAEHALSG VSHFAVNGRD
     KIVARVVAAD GFALRKILIP LISHLRKGAS VPRVWTL