ID   URED_SPOPA              Reviewed;         257 AA.
AC   Q45347; Q93KP8;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
OS   Sporosarcina pasteurii (Bacillus pasteurii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Planococcaceae; Sporosarcina.
OX   NCBI_TaxID=1474;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 11859 / DSM 33 / NCIB 8841 / NCTC 4822;
RX   PubMed=12072968; DOI=10.1007/s00775-002-0341-7;
RA   Ciurli S., Safarov N., Miletti S., Dikiy A., Christensen S.K.,
RA   Kornetzky K., Bryant D.A., Vandenberghe I., Devreese B., Samyn B.,
RA   Remaut H., Van Beeumen J.;
RT   "Molecular characterization of Bacillus pasteurii UreE, a metal-binding
RT   chaperone for the assembly of the urease active site.";
RL   J. Biol. Inorg. Chem. 7:623-631(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-207.
RC   STRAIN=ATCC 11859 / DSM 33 / NCIB 8841 / NCTC 4822;
RA   You J.-H., Kim J.-G., Song B.-H., Lee M.-H., Kim S.-D.;
RT   "Genetic organization and nucleotide sequence of the ure gene cluster in
RT   Bacillus pasteurii.";
RL   Mol. Cells 5:359-369(1995).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AF361945; AAK43720.1; -; Genomic_DNA.
DR   EMBL; U29368; AAA73990.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q45347; -.
DR   SMR; Q45347; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..257
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067605"
FT   CONFLICT        192..195
FT                   /note="MWFV -> WVD (in Ref. 2; AAA73990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        200
FT                   /note="E -> G (in Ref. 2; AAA73990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        203..207
FT                   /note="DIREL -> RILGS (in Ref. 2; AAA73990)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   257 AA;  29291 MW;  5889FD6328420B45 CRC64;
     MEFQYRGNKT VLSNCYQNPP LRASRPLYIN PANRSEATVY LVETSGGIVE GDHNVFDIDI
     KEGADVCLIP QSATKIYPSY NGIWSSQDMD ITIGPKASLS FKTEAVIPFE QARFNSKTVI
     QMTSDSTFLW GDILSPGRVA RGEVFEYTDV RTNFQVWMDD ECLIYDPLLI SKDNMGLKKM
     GMLEDHLFIG SMWFVTPTIE EFDIRELNER LQESPHSKAS ASMLEGKAVN VRWLASDLVD
     LKKEMNRIWD EFANYIV