ID   URED_STAA3              Reviewed;         278 AA.
AC   Q2FEJ9;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=SAUSA300_2244;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000255; ABD21016.1; -; Genomic_DNA.
DR   RefSeq; WP_000344352.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FEJ9; -.
DR   SMR; Q2FEJ9; -.
DR   EnsemblBacteria; ABD21016; ABD21016; SAUSA300_2244.
DR   KEGG; saa:SAUSA300_2244; -.
DR   HOGENOM; CLU_056339_5_0_9; -.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..278
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346603"
SQ   SEQUENCE   278 AA;  32437 MW;  1A66C8306973C346 CRC64;
     MDEQQWTGQL DLTVFFDGNR SVSRDIFFEK ALKVIRPVYL NQSTIPTFYI VNVGGGYLDG
     DRYRMNVNVE DNAKVTLTSQ GATKIYKTPS NHVEQYQTFN LKDNAYLEYV ADPIIAYENA
     KFYQHNTFNL NNSSSLFYTD ILTPGYSKTG EAFKYQYMHL INEIYIEDEL VTYDNLLLNP
     NKQSINEIGY MEHYSHYGSA YFIHEDVNQK LIDSVYETIS SYSNTFDCRV AISQLPTHGF
     AVRIFAYRTQ IIEKILGTIQ SYIAENIYDR KLDFLRKY