ID   URED_STAA8              Reviewed;         278 AA.
AC   Q2G272;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=SAOUHSC_02565;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000253; ABD31577.1; -; Genomic_DNA.
DR   RefSeq; WP_000344352.1; NZ_LS483365.1.
DR   RefSeq; YP_501026.1; NC_007795.1.
DR   AlphaFoldDB; Q2G272; -.
DR   SMR; Q2G272; -.
DR   STRING; 1280.SAXN108_2542; -.
DR   EnsemblBacteria; ABD31577; ABD31577; SAOUHSC_02565.
DR   GeneID; 3921562; -.
DR   KEGG; sao:SAOUHSC_02565; -.
DR   PATRIC; fig|93061.5.peg.2314; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_0_9; -.
DR   OMA; CQHIIVH; -.
DR   PRO; PR:Q2G272; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346600"
SQ   SEQUENCE   278 AA;  32437 MW;  1A66C8306973C346 CRC64;
     MDEQQWTGQL DLTVFFDGNR SVSRDIFFEK ALKVIRPVYL NQSTIPTFYI VNVGGGYLDG
     DRYRMNVNVE DNAKVTLTSQ GATKIYKTPS NHVEQYQTFN LKDNAYLEYV ADPIIAYENA
     KFYQHNTFNL NNSSSLFYTD ILTPGYSKTG EAFKYQYMHL INEIYIEDEL VTYDNLLLNP
     NKQSINEIGY MEHYSHYGSA YFIHEDVNQK LIDSVYETIS SYSNTFDCRV AISQLPTHGF
     AVRIFAYRTQ IIEKILGTIQ SYIAENIYDR KLDFLRKY