ID   URED_STAEQ              Reviewed;         278 AA.
AC   Q5HLV7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=SERP1875;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000029; AAW55255.1; -; Genomic_DNA.
DR   RefSeq; WP_002489285.1; NC_002976.3.
DR   AlphaFoldDB; Q5HLV7; -.
DR   SMR; Q5HLV7; -.
DR   STRING; 176279.SERP1875; -.
DR   EnsemblBacteria; AAW55255; AAW55255; SERP1875.
DR   GeneID; 50018032; -.
DR   KEGG; ser:SERP1875; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_0_9; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..278
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346605"
SQ   SEQUENCE   278 AA;  32284 MW;  CAFA064C1448D0D0 CRC64;
     MAEQHWTGQL DLTVFNNGES SKARNIFFEK ALKVLRPIYL EQSPVPTFYI VNVGGGYLDG
     DRYRVNVNLE DNAQVTLTSQ GATKIYKTPN DHVEQYQTFN LSNQSYMEFV ADPIIAYENA
     KFFQHNTFNL KEDSAIFYTD ILTPGYSSNG QDFTYNYMHL TNEIYIDNQL VVFDNMMLSP
     DKSRLDGIGY MENYTHLGSA YFIHPDVNQS FIDDIYVAVA DFQKQYDCRI GISQLPTHGL
     AVRILTKRTQ IIEEILTRVQ SYINQTIYHR QINFLRKY