ID   URED_STAES              Reviewed;         278 AA.
AC   Q8CNC5;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=SE_1867;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AE015929; AAO05508.1; -; Genomic_DNA.
DR   RefSeq; NP_765422.1; NC_004461.1.
DR   RefSeq; WP_002485372.1; NZ_WBME01000034.1.
DR   AlphaFoldDB; Q8CNC5; -.
DR   SMR; Q8CNC5; -.
DR   STRING; 176280.SE_1867; -.
DR   DNASU; 1055730; -.
DR   EnsemblBacteria; AAO05508; AAO05508; SE_1867.
DR   KEGG; sep:SE_1867; -.
DR   PATRIC; fig|176280.10.peg.1824; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_0_9; -.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..278
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346604"
SQ   SEQUENCE   278 AA;  32304 MW;  485CB37DE9F0EC22 CRC64;
     MAEQRWTGQL DLTVFNNGQS SKARNIFFEK ALKVLRPIYL EQSPVPTFYI VNVGGGYLDG
     DRYRVNVNLE DNAQVTLTSQ GATKIYKTPN DHVEQYQTFN LSNQSYMEFV ADPIIAYENA
     KFFQHNTFNL KEDSAMFYTD ILTPGYSSNG QDFTYNYMHL INEIYIDNQL VVFDNMMLSP
     DKSRLDGIGY MENYTHLGSA YFIHPDVNQS FIDDIYAAVA DFQKQYDCRI GISQLPTHGL
     AVRILTKRTQ IIEEILTRVQ SYINQTIYHR QINFLRKY