ID   URED_STAS1              Reviewed;         280 AA.
AC   Q4A0J9;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=SSP0259;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AP008934; BAE17404.1; -; Genomic_DNA.
DR   RefSeq; WP_002482214.1; NZ_MTGA01000037.1.
DR   AlphaFoldDB; Q4A0J9; -.
DR   SMR; Q4A0J9; -.
DR   STRING; 342451.SSP0259; -.
DR   DNASU; 3616065; -.
DR   EnsemblBacteria; BAE17404; BAE17404; SSP0259.
DR   GeneID; 66866425; -.
DR   KEGG; ssp:SSP0259; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_0_9; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..280
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000346606"
SQ   SEQUENCE   280 AA;  32522 MW;  0AA450A17F097188 CRC64;
     MSNNKQAWTG QLDLSVFNNG KKSVARDVFF EKALKVMRPV YLNQSDIPTF YIVNVGGGYL
     DGDRYTMNFN IDSDAKVILT SQGATKIYKT LNDHVEQYQT FNIKNNGYAE YVGDPIIAFE
     NAKFYQHNVF NLESTASLFY TDILTPGYSK SDKRFSYTYM HLLNEIYVDD ALVTFDNMLL
     DPQKQNVDGL GYMEDYTHLG SCYFIHPSVN QKFIEQVYEE IKHFQHKYDC RFGITHLPTH
     GFSLRILSNK TQVIESIITA VQCYVVKQIF DRDVDFLRKY