ID   URED_STRCO              Reviewed;         254 AA.
AC   Q9FCD6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=SCO1231;
GN   ORFNames=2SCG1.06c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL939108; CAC01455.1; -; Genomic_DNA.
DR   RefSeq; NP_625519.1; NC_003888.3.
DR   RefSeq; WP_011027661.1; NZ_VNID01000006.1.
DR   AlphaFoldDB; Q9FCD6; -.
DR   SMR; Q9FCD6; -.
DR   STRING; 100226.SCO1231; -.
DR   GeneID; 1096654; -.
DR   KEGG; sco:SCO1231; -.
DR   PATRIC; fig|100226.15.peg.1230; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_055097_2_0_11; -.
DR   InParanoid; Q9FCD6; -.
DR   OMA; MARFCAQ; -.
DR   PhylomeDB; Q9FCD6; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..254
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340521"
SQ   SEQUENCE   254 AA;  25779 MW;  95198EB42ACAE92F CRC64;
     MTTVAGGVRA SARVLARGDG RGGTVLPVLE GEGPLAVRRT RGSGAEARVM LVGAMSGPLG
     GDHFEVGAHA ANGARLRVGS AAATLALPGQ DKAGARYDVR LTVDDDAELY WLPEQLISAG
     GSDLTVTTSV DLAAGARLLL REEQVLGRAG EEPGRLTSRL TLRIDGRGVL DQELLCGPGA
     PGGWDGPAGL AGHRAVGQLV VVRPGFATEP PAARVFEEGA AVMPLAGPAA LVTAVAPDAL
     RLRRLLDGAL ASLD