ID   URED_STRE5              Reviewed;         279 AA.
AC   Q55058; F8HGJ6;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=Ssal_01895;
OS   Streptococcus salivarius (strain 57.I).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1046629;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=57.I;
RX   PubMed=8550211; DOI=10.1128/iai.64.2.585-592.1996;
RA   Chen Y.-Y.M., Clancy K.A., Burne R.A.;
RT   "Streptococcus salivarius urease: genetic and biochemical characterization
RT   and expression in a dental plaque streptococcus.";
RL   Infect. Immun. 64:585-592(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=57.I;
RX   PubMed=21914897; DOI=10.1128/jb.05670-11;
RA   Geng J., Huang S.C., Li S., Hu S., Chen Y.Y.;
RT   "Complete genome sequence of the ureolytic Streptococcus salivarius strain
RT   57.I.";
RL   J. Bacteriol. 193:5596-5597(2011).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; U35248; AAC43568.1; -; Genomic_DNA.
DR   EMBL; CP002888; AEJ54132.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q55058; -.
DR   SMR; Q55058; -.
DR   STRING; 1046629.Ssal_01895; -.
DR   PRIDE; Q55058; -.
DR   EnsemblBacteria; AEJ54132; AEJ54132; Ssal_01895.
DR   KEGG; stf:Ssal_01895; -.
DR   PATRIC; fig|1046629.4.peg.1682; -.
DR   eggNOG; COG0829; Bacteria.
DR   OMA; CQHIIVH; -.
DR   Proteomes; UP000000293; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..279
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067615"
SQ   SEQUENCE   279 AA;  32316 MW;  DB5DD80C622CFB1B CRC64;
     MTQAYDGFVH LGFSNRNGRT ISHKKYQEGN SRVSADNSDA NGVPYYFLIN MGGGFVEGEQ
     YQVTIDVNKD AHALVTTQTP TYVYKCEKGQ LTHQNTSITL EENSYLEYMA DEVIPYLRSR
     YFQTSRIDMD KSAHLIYSDG VTAGWSHEDL PFQYHYFRNL TQIYQDDELV YSDQTLLEPQ
     KQDMFKLGYF EGWRNYNSLV MVSPNIDEAF VKALQKHLEN LNLESDFAIS SLDIPGLVLR
     ILGKTAEDNR RVIYSCADYF RQEIHGLTPL NLRKNDMRR