ID   URED_SYNPV              Reviewed;         319 AA.
AC   O87399;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
OS   Synechococcus sp. (strain WH7805).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=59931;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10075427; DOI=10.1099/13500872-145-2-447;
RA   Collier J.L., Brahamsha B., Palenik B.;
RT   "The marine cyanobacterium Synechococcus sp. WH7805 requires urease (urea
RT   amidohydrolase, EC 3.5.1.5) to utilize urea as a nitrogen source:
RT   molecular-genetic and biochemical analysis of the enzyme.";
RL   Microbiology 145:447-459(1999).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AF056189; AAC61499.1; -; Genomic_DNA.
DR   RefSeq; WP_006042765.1; NZ_CH724168.1.
DR   AlphaFoldDB; O87399; -.
DR   SMR; O87399; -.
DR   STRING; 59931.WH7805_09824; -.
DR   PRIDE; O87399; -.
DR   eggNOG; COG0829; Bacteria.
DR   OMA; CQHIIVH; -.
DR   PhylomeDB; O87399; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..319
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067616"
FT   REGION          298..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        302..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   319 AA;  35401 MW;  0E491227E8E4771A CRC64;
     MQRLDPWHGR CELRFEHRQT EHGDAGTVHQ GGCSAPFKLL RAEQGKNGRC ELPILHTAGG
     LVGGDQLSIA LDLNTNSRCL ITSVAAQKVY GSIGRSRLHP EGQWARQQVH CKLANSSDLE
     WLPQELVLYA NALFEQHLTV QLPANASFLS AEIVRLGRTA AGETLQQGRW RSALSLCRRS
     VEPHQASRWE LVDRLDLGGD ALNDQHGLNK RPVFGSLVWA APMPLNGEAL TQLLELVRSD
     REGLNGTMRC SALDQGLVAR YSGPSSRDAR FWFSRIWART RALRALSAPQ IPRVWPLQEQ
     PLPPSSFKTN TAVPAVRTH