ID   URED_SYNS3              Reviewed;         296 AA.
AC   Q0I659;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=sync_2876;
OS   Synechococcus sp. (strain CC9311).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC   unclassified Synechococcus.
OX   NCBI_TaxID=64471;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9311;
RX   PubMed=16938853; DOI=10.1073/pnas.0602963103;
RA   Palenik B., Ren Q., Dupont C.L., Myers G.S., Heidelberg J.F., Badger J.H.,
RA   Madupu R., Nelson W.C., Brinkac L.M., Dodson R.J., Durkin A.S.,
RA   Daugherty S.C., Sullivan S.A., Khouri H., Mohamoud Y., Halpin R.,
RA   Paulsen I.T.;
RT   "Genome sequence of Synechococcus CC9311: insights into adaptation to a
RT   coastal environment.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:13555-13559(2006).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000435; ABI46405.1; -; Genomic_DNA.
DR   RefSeq; WP_011620763.1; NC_008319.1.
DR   AlphaFoldDB; Q0I659; -.
DR   SMR; Q0I659; -.
DR   STRING; 64471.sync_2876; -.
DR   EnsemblBacteria; ABI46405; ABI46405; sync_2876.
DR   KEGG; syg:sync_2876; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_4_0_3; -.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000001961; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..296
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340523"
SQ   SEQUENCE   296 AA;  33004 MW;  EFCFAE7F66C5BCDA CRC64;
     MQRLDPWHGT CNLQFVAGSS GSQFQGGCTA PLKLMRAERG ENGRCELPLL HTAGGLVGGD
     QLSINLGLRP NSRCLLTSVA AQKIYGSIGR SQLHPLGTWA RQQVSAELDA DSDLEWLPQE
     LVLYADALFE QNLSVTLPMD GSFLSAEIVR LGRTAANETL GQGCWRSDVQ IQRQTSEGRR
     WELVDRLEIS DDALKGFHGL NQQPVFGTLV WAAPFPLQTT KINNLLDDIR QDRKALEGQM
     HCGALPQGLI ARYSGFSSRD ARFWFSRIWA RTRQARNLAS PKIPRVWPLQ EYPLRP