ID   URED_SYNY3              Reviewed;         270 AA.
AC   P73047;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=sll1639;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA17068.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000022; BAA17068.1; ALT_INIT; Genomic_DNA.
DR   PIR; S75154; S75154.
DR   AlphaFoldDB; P73047; -.
DR   SMR; P73047; -.
DR   STRING; 1148.1652144; -.
DR   PaxDb; P73047; -.
DR   EnsemblBacteria; BAA17068; BAA17068; BAA17068.
DR   KEGG; syn:sll1639; -.
DR   eggNOG; COG0829; Bacteria.
DR   InParanoid; P73047; -.
DR   PhylomeDB; P73047; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..270
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067617"
SQ   SEQUENCE   270 AA;  30522 MW;  FAA820E257E69286 CRC64;
     MLSASTVNPS APWQANLWLR YDRPGHRTRM VECLVQAPLK VQRSFYPDDT GQCQTMLLHT
     GGGMVGGDRL GYDIVLEAQS DVCFTSASAG KIYRSLGPWS EQTVNLEVRV GASVLWCPQE
     TIIFDQARYQ QNFCIKLQEQ ARFKGWEIVR LGRTARGEKF TQGHWRSSWE IWQGDKLIWG
     ERQQLIGSEQ LYESPNALAG FTCLGTYVDL SRSFDQDLVH QAQEIIHSQG RSPQFGLTLT
     ATQGLIARYR GNSTQEVKDI FTQLSQVISP