ID   URED_THEVB              Reviewed;         274 AA.
AC   Q8DLF7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=tlr0536;
OS   Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC   Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; BA000039; BAC08088.1; -; Genomic_DNA.
DR   RefSeq; NP_681326.1; NC_004113.1.
DR   RefSeq; WP_011056386.1; NC_004113.1.
DR   AlphaFoldDB; Q8DLF7; -.
DR   SMR; Q8DLF7; -.
DR   STRING; 197221.22294257; -.
DR   EnsemblBacteria; BAC08088; BAC08088; BAC08088.
DR   KEGG; tel:tlr0536; -.
DR   PATRIC; fig|197221.4.peg.565; -.
DR   eggNOG; COG0829; Bacteria.
DR   OMA; CQHIIVH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..274
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340522"
SQ   SEQUENCE   274 AA;  31180 MW;  F6A82A4C0843C5DD CRC64;
     MAGWLGELEL VYAWRRGQTI PVRAYASAPL KLQRSFYPEG KPICHSVILH TAGGYVGGDR
     LHQKITLEPQ CRVLLTTPAA TKVYGRAQIP VEQTLHCHVA DEAVLEWLPQ ETIIFAGAQF
     HQRLRIDLAP QAQVGLWEMT RFGRTARGEV FNRGYWRYHT EVWQGGVPLW IDRQRIEGTK
     MMLTAMNALQ GCPLMGTLAW VGREVSSEQI QRLRDLAMGI QGEMGVSTLI RGVVCRYRGH
     SMAELRRWFV AAWQLLRPGQ GSHPLVCYPR VWPR