ID   URED_UREP2              Reviewed;         287 AA.
AC   B1AJ69;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=UPA3_0447;
OS   Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=505682;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27815 / 27 / NCTC 11736;
RA   Methe B.A., Glass J., Waites K., Shrivastava S.;
RT   "Genome sequence of Ureaplasma parvum serovar 3.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; CP000942; ACA32694.1; -; Genomic_DNA.
DR   RefSeq; WP_006688613.1; NC_010503.1.
DR   AlphaFoldDB; B1AJ69; -.
DR   SMR; B1AJ69; -.
DR   EnsemblBacteria; ACA32694; ACA32694; UPA3_0447.
DR   GeneID; 29672331; -.
DR   KEGG; upa:UPA3_0447; -.
DR   HOGENOM; CLU_056339_5_0_14; -.
DR   OMA; IPFENAH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002162; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..287
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_1000215124"
SQ   SEQUENCE   287 AA;  33247 MW;  97629F1F812C77F1 CRC64;
     MILNKEKIKN YAAYLYIKVA YDQAHSKMAH TVYFTNFYRS SKPLFLDEED PINPCFQTIS
     MGGGYVSGEI YRSDFEINDD ARCIITTQSS AKAYKTVDGK TSEQHTNITL GKNSILEYIS
     DNVIVYEDGK FAQFNNFKMD SSATLIYTEC FGPGWSPHGS AYQYEKMYLN TKIYYDDKLV
     LFDNLKFQPR KNDESAFGIM DGYHYCGTMI VINQQVIEDD VIKIRDLVKE KYPDMDMIFG
     VSRMDIPGLG LRVLANTYYH VEKINAVAHD YFRRKLFNKK PLILRKP