ID   URED_UREPA              Reviewed;         287 AA.
AC   Q56562; Q9PQ60;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384}; OrderedLocusNames=UU428;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93.
RC   STRAIN=ATCC 27813 / 7 / Serovar 1;
RX   PubMed=8550495; DOI=10.1128/jb.178.3.647-655.1996;
RA   Neyrolles O., Ferris S., Behbahani N., Montagnier L., Blanchard A.;
RT   "Organization of Ureaplasma urealyticum urease gene cluster and expression
RT   in a suppressor strain of Escherichia coli.";
RL   J. Bacteriol. 178:647-655(1996).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AF222894; AAF30840.1; -; Genomic_DNA.
DR   EMBL; L40489; AAA89193.1; -; Genomic_DNA.
DR   PIR; F82893; F82893.
DR   RefSeq; WP_006688613.1; NC_002162.1.
DR   AlphaFoldDB; Q56562; -.
DR   SMR; Q56562; -.
DR   STRING; 273119.UU428; -.
DR   EnsemblBacteria; AAF30840; AAF30840; UU428.
DR   GeneID; 29672331; -.
DR   KEGG; uur:UU428; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_0_14; -.
DR   OMA; IPFENAH; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..287
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000067618"
FT   CONFLICT        70
FT                   /note="I -> V (in Ref. 2; AAA89193)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        80..82
FT                   /note="DAR -> AAC (in Ref. 2; AAA89193)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        91
FT                   /note="A -> R (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   287 AA;  33247 MW;  97629F1F812C77F1 CRC64;
     MILNKEKIKN YAAYLYIKVA YDQAHSKMAH TVYFTNFYRS SKPLFLDEED PINPCFQTIS
     MGGGYVSGEI YRSDFEINDD ARCIITTQSS AKAYKTVDGK TSEQHTNITL GKNSILEYIS
     DNVIVYEDGK FAQFNNFKMD SSATLIYTEC FGPGWSPHGS AYQYEKMYLN TKIYYDDKLV
     LFDNLKFQPR KNDESAFGIM DGYHYCGTMI VINQQVIEDD VIKIRDLVKE KYPDMDMIFG
     VSRMDIPGLG LRVLANTYYH VEKINAVAHD YFRRKLFNKK PLILRKP