ID   URED_UREU1              Reviewed;         287 AA.
AC   B5ZBS5; Q56563;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Urease accessory protein UreD;
GN   Name=ureD; OrderedLocusNames=UUR10_0473;
OS   Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=565575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15388749; DOI=10.1099/ijs.0.63073-0;
RA   Kong F., Gilbert G.L.;
RT   "Postgenomic taxonomy of human ureaplasmas - a case study based on multiple
RT   gene sequences.";
RL   Int. J. Syst. Evol. Microbiol. 54:1815-1821(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33699 / Western;
RA   Shrivastava S., Methe B.A., Glass J., White K., Duffy L.B.;
RT   "Genome sequence of Ureaplasma urealyticum serovar 10 ATCC-33699.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000250}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000305}.
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DR   EMBL; AF085726; AAG10336.1; -; Genomic_DNA.
DR   EMBL; CP001184; ACI60186.1; -; Genomic_DNA.
DR   RefSeq; WP_004025994.1; NC_011374.1.
DR   AlphaFoldDB; B5ZBS5; -.
DR   SMR; B5ZBS5; -.
DR   STRING; 565575.UUR10_0473; -.
DR   EnsemblBacteria; ACI60186; ACI60186; UUR10_0473.
DR   GeneID; 45016016; -.
DR   KEGG; uue:UUR10_0473; -.
DR   eggNOG; COG0829; Bacteria.
DR   HOGENOM; CLU_056339_5_0_14; -.
DR   OMA; IPFENAH; -.
DR   OrthoDB; 1764668at2; -.
DR   Proteomes; UP000002018; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..287
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000380258"
SQ   SEQUENCE   287 AA;  33160 MW;  893323ACA41146B1 CRC64;
     MILSKEKINN YAAYLYIKVA YDEAHNKMAH TVYFTNFYRS SKPLFLDEED PINPCFQTIS
     MGGGYVSGEV YRSDFEVEAN ARCIITTQSS AKAYKAVDGK TSEQHTNITL GKNSILEYIS
     DNVIVYEDGK FAQFNNFKMD STATLIYTEC FGPGWSPHGS AYQYEKMYLN TKIYYDNKLV
     LFDNLKFQPR KNDESAFGIM DGYHYCGTMI VINQEVVEED VIKIRDLVKE KYPDMDMIFG
     VSRMDIPGLG LRVLANTYYH VEKINAVAHD YFRRKLFNKK PLILRKP