URED_UREUR
ID URED_UREUR Reviewed; 287 AA.
AC P0CB03; Q56563;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 25.
DE RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
OS Ureaplasma urealyticum (Ureaplasma urealyticum biotype 2).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX NCBI_TaxID=2130;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 27618 / CIP 103755 / NCTC 10177 / T960 / Serovar 8;
RX PubMed=8550495; DOI=10.1128/jb.178.3.647-655.1996;
RA Neyrolles O., Ferris S., Behbahani N., Montagnier L., Blanchard A.;
RT "Organization of Ureaplasma urealyticum urease gene cluster and expression
RT in a suppressor strain of Escherichia coli.";
RL J. Bacteriol. 178:647-655(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 27618 / CIP 103755 / NCTC 10177 / T960 / Serovar 8,
RC ATCC 27814 / 23 / Serovar 2, ATCC 27816 / 58 / Serovar 4,
RC ATCC 27817 / 354 / Serovar 5, ATCC 27819 / Co / Serovar 7,
RC ATCC 33175 / Vancouver / Serovar 9, ATCC 33695 / K2 / Serovar 11,
RC ATCC 33696 / U24 / Serovar 12, and ATCC 33698 / U38 / Serovar 13;
RX PubMed=15388749; DOI=10.1099/ijs.0.63073-0;
RA Kong F., Gilbert G.L.;
RT "Postgenomic taxonomy of human ureaplasmas - a case study based on multiple
RT gene sequences.";
RL Int. J. Syst. Evol. Microbiol. 54:1815-1821(2004).
CC -!- FUNCTION: Required for maturation of urease via the functional
CC incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC Rule:MF_01384}.
CC -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC hydrolysis-dependent molecular chaperone, activating the urease
CC apoprotein by helping to assemble the nickel containing metallocenter
CC of UreC. The UreE protein probably delivers the nickel.
CC {ECO:0000255|HAMAP-Rule:MF_01384}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC Rule:MF_01384}.
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DR EMBL; L40490; AAA89194.1; -; Genomic_DNA.
DR EMBL; AF085720; AAG10306.1; -; Genomic_DNA.
DR EMBL; AF085721; AAG10311.1; -; Genomic_DNA.
DR EMBL; AF085722; AAG10316.1; -; Genomic_DNA.
DR EMBL; AF085723; AAG10321.1; -; Genomic_DNA.
DR EMBL; AF085724; AAG10326.1; -; Genomic_DNA.
DR EMBL; AF085725; AAG10331.1; -; Genomic_DNA.
DR EMBL; AF085727; AAG10341.1; -; Genomic_DNA.
DR EMBL; AF085728; AAG10346.1; -; Genomic_DNA.
DR EMBL; AF085729; AAG10351.1; -; Genomic_DNA.
DR RefSeq; WP_004025994.1; NZ_QOKT01000007.1.
DR AlphaFoldDB; P0CB03; -.
DR SMR; P0CB03; -.
DR GeneID; 45016016; -.
DR OMA; IPFENAH; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR HAMAP; MF_01384; UreD; 1.
DR InterPro; IPR002669; UreD.
DR PANTHER; PTHR33643; PTHR33643; 1.
DR Pfam; PF01774; UreD; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm; Nickel insertion.
FT CHAIN 1..287
FT /note="Urease accessory protein UreD"
FT /id="PRO_0000067619"
SQ SEQUENCE 287 AA; 33160 MW; 893323ACA41146B1 CRC64;
MILSKEKINN YAAYLYIKVA YDEAHNKMAH TVYFTNFYRS SKPLFLDEED PINPCFQTIS
MGGGYVSGEV YRSDFEVEAN ARCIITTQSS AKAYKAVDGK TSEQHTNITL GKNSILEYIS
DNVIVYEDGK FAQFNNFKMD STATLIYTEC FGPGWSPHGS AYQYEKMYLN TKIYYDNKLV
LFDNLKFQPR KNDESAFGIM DGYHYCGTMI VINQEVVEED VIKIRDLVKE KYPDMDMIFG
VSRMDIPGLG LRVLANTYYH VEKINAVAHD YFRRKLFNKK PLILRKP
