ID   URED_VIBPH              Reviewed;         280 AA.
AC   Q9FAS8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Urease accessory protein UreD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
OS   Vibrio parahaemolyticus.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=670;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TH3996;
RX   PubMed=10992480; DOI=10.1128/iai.68.10.5742-5748.2000;
RA   Park K.-S., Iida T., Yamaichi Y., Oyagi T., Yamamoto K., Honda T.;
RT   "Genetic characterization of DNA region containing the trh and ure genes of
RT   Vibrio parahaemolyticus.";
RL   Infect. Immun. 68:5742-5748(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TH3996;
RX   PubMed=19075025; DOI=10.1128/iai.01184-08;
RA   Okada N., Iida T., Park K.-S., Goto N., Yasunaga T., Hiyoshi H.,
RA   Matsuda S., Kodama T., Honda T.;
RT   "Identification and characterization of a novel type III secretion system
RT   in trh-positive Vibrio parahaemolyticus strain TH3996 reveal genetic
RT   lineage and diversity of pathogenic machinery beyond the species level.";
RL   Infect. Immun. 77:904-913(2009).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
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DR   EMBL; AB455531; BAB13785.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9FAS8; -.
DR   SMR; Q9FAS8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Nickel insertion.
FT   CHAIN           1..280
FT                   /note="Urease accessory protein UreD"
FT                   /id="PRO_0000340532"
SQ   SEQUENCE   280 AA;  31479 MW;  E39B14960124A942 CRC64;
     MFDMSSSSSG WVAEIYLRYQ LKRGITRLIE RKQVGPLMVQ RPFYPEHGSS HTYLLHPPGG
     VVAGDLLSIN VVVEEGAHSL ITTPGATKFY RSIGEVARQA QNLRVEEDAF LEWLPLENIF
     FPSAAAILET NISLKVSSRF IGWDMLCFGR PMLNETFESG NVIGQTKIFV DDKLILADSL
     CVDSTKFKAA GMREFPMLGA MYIYPASEAL KELVHRSIQD YLMQTKESLE IGLTDVDGLL
     TVRALGHQTE EIMGCLVLIW KTCRKLWLGY VPDIPRIWAT