ID   URED_YERPE              Reviewed;         277 AA.
AC   Q9ZFR5;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Putative urease accessory protein UreD;
GN   Name=ureD {ECO:0000255|HAMAP-Rule:MF_01384};
GN   OrderedLocusNames=YPO2671, y1243, YP_2472;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION AS A PSEUDOGENE,
RP   REVERSION FREQUENCY, AND LACK OF ROLE IN VIRULENCE.
RC   STRAIN=6/69M;
RX   PubMed=11119503; DOI=10.1128/iai.69.1.170-176.2001;
RA   Sebbane F., Devalckenaere A., Foulon J., Carniel E., Simonet M.;
RT   "Silencing and reactivation of urease in Yersinia pestis is determined by
RT   one G residue at a specific position in the ureD gene.";
RL   Infect. Immun. 69:170-176(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Required for maturation of urease via the functional
CC       incorporation of the urease nickel metallocenter. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP-
CC       hydrolysis-dependent molecular chaperone, activating the urease
CC       apoprotein by helping to assemble the nickel containing metallocenter
CC       of UreC. The UreE protein probably delivers the nickel.
CC       {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01384}.
CC   -!- SIMILARITY: Belongs to the UreD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01384}.
CC   -!- CAUTION: Could be the product of a pseudogene. This gene encodes a non-
CC       functional protein due to an extra G nucleotide which gives rise to a
CC       truncated protein. This reverts with a frequency of 10 -4 to 10 -5 on
CC       urea containing agar. This reversion does not effect virulence in mice
CC       in any detectable fashion, suggesting urease is not important in the
CC       virulence of Y.pestis (PubMed:11119503). {ECO:0000305|PubMed:11119503}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF095636; AAC78638.1; -; Genomic_DNA.
DR   EMBL; AL590842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AE009952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AE017042; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q9ZFR5; -.
DR   SMR; Q9ZFR5; -.
DR   KEGG; ypj:CH55_1500; -.
DR   KEGG; ypl:CH46_2438; -.
DR   KEGG; ypv:BZ15_862; -.
DR   KEGG; ypw:CH59_3551; -.
DR   OMA; IPFENAH; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   HAMAP; MF_01384; UreD; 1.
DR   InterPro; IPR002669; UreD.
DR   PANTHER; PTHR33643; PTHR33643; 1.
DR   Pfam; PF01774; UreD; 1.
PE   5: Uncertain;
KW   Chaperone; Cytoplasm; Nickel insertion; Reference proteome.
FT   CHAIN           1..277
FT                   /note="Putative urease accessory protein UreD"
FT                   /id="PRO_0000067621"
SQ   SEQUENCE   277 AA;  30816 MW;  3D528D8890320940 CRC64;
     MTAQSQNIVE TPSRVRAHAL GVNAPELAKY QDEPAQMRSG AVGKSGYLKL RFAKREHCSI
     LAEMERRVPS LVQKALYWDE EIPELPCVTM ISTSGCILQG DRLATDVHVE AGACAHVTTQ
     SATKVHMMNA NYASQIQNFI VEEGGYLEFM PDPLIPHRNS RFITDTTISI HPTATAIYSE
     VLMSGRKYHH ADERFGFDVY SSRVAAQNLA GKELFVEKYV LEPKVESLDA VGVMQTFDAF
     GNVILLTPKE HHDRILARVP AHFDIKGGDC QRRDAST